Searchable abstracts of presentations at key conferences in endocrinology

ea0081p130 | Endocrine-Related Cancer | ECE2022

Origins of progesterone in male mice

Collden Hannah , Hagberg Thulin Malin , Landin Andreas , Norlen Anna-Karin , Ryberg Henrik , Wu Jianyao , Gustafsson Karin L , Grahnemo Louise , Nilsson Karin , Sjogren Klara , Poutanen Matti , Vandenput Liesbeth , Ohlsson Claes

The role of progesterone in male physiology is mainly unknown. We recently observed that progesterone was the most abundant sex hormone in orchiectomized (ORX) mice with most of it stored in white adipose tissue (WAT) (1). The aim of the present study was to use a sensitive and validated gas chromatography/tandem mass spectroscopy method to determine the origins of progesterone in male mice. Tissue levels of progesterone were high in adrenals of male mice, indicating that male...